OssiGel
Osteoinductive human ECM matrix
OssiGel is an off-the-shelf, injectable gel that enables the formation of human miniature bone organs from donor-derived cells in research animals. Its purpose is to serve as a biologically relevant human-specific preclinical platform for studying:
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Bone formation/regeneration.
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Tumor development and progression in the bone.
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Personalized therapies, especially for bone-developing cancers.
In essence, OssiGel is a robust preclinical tool that aspires to replace ineffective and poorly translatable in vivo models in order to improve precision oncology by offering a relevant and customizable model system for testing therapeutic strategies on a per-patient basis.
How it works
By simply mixing human cells with OssiGel, users can choose between two powerful applications:
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In Vivo Polymerization: Inject the cell-laden OssiGel subcutaneously into immunodeficient mice, where it polymerizes in situ and forms human ossicles—miniature bone organs that mimic the human bone marrow microenvironment.
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In Vitro Polymerization: Polymerize the construct in lab conditions to create tissue-engineered constructs for controlled studies, drug screening, or transplantation. These ossicles can later be implanted subcutaneously to establish a functional humanized bone marrow niche.
Whether for regenerative medicine, hematopoietic research, or immune-tumor interaction modeling, OssiGel offers a versatile, reproducible, and translational solution for studying the human bone and bone marrow microenvironment.
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Product Packages
CRO Services
Our mission is to bring preclinical research closer to clinical relevance by enabling the study of tumor development, progression, and therapeutic response in a controlled, yet patient-specific environment. Every ossicle reflects the unique bone complexity of its cell donor—being a healthy, patient donor, iPSC or other cell source.
In vivo humanized bone organ generation
At Dhalion, we develop patient-specific, miniaturized human bone tissues—called ossicles—from donor-derived cells. These in vivo tissues form the basis of a living, humanized platform for studying bone and bone marrow biology in real time.
Histological, molecular, and imaging-based analysis​
Comprehensive characterization of tissue samples through histological staining, cellular and molecular profiling, and advanced image analysis techniques to uncover cellular organization, molecular signatures, and spatial patterns.
Custom study design and execution
With a strong foundation in developmental biology and translational research, we offer flexible, expert-driven services to accelerate your drug discovery pipeline. Do you have your own idea but don't know how to best execute it? Contact us to help you realize it.