Publications
The Dhalion team is committed to advancing science. Discover the rigorous scientific foundation behind our innovation—explore our peer-reviewed publications that showcase the research findings and validation driving the refinement of our in vivo modeling technology.
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis
We demonstrated not only superior engraftment of human cord blood hematopoietic cells and primary acute myeloid leukemia samples, but also validated hOss as a metastatic site for breast cancer cells and neuroblastoma patient-derived xenograft cells. Collectively, our human mini-bones constitute a powerful preclinical platform to model bone-developing tumors using patient-derived material.
Grigoryan et al. 2022, Sci. Transl. Med.
Development of humanized sssicles: Bridging the hematopoietic gap
In this review, we described the specificities of the hOss models and highlighted their potential and limits. Ultimately, we proposed directions for the development of hOss as a technological platform for human hematopoietic studies.
Dupard, Grigoryan et al. 2020, Trends Mol Med
Manufacturing of human tissues as off-the-shelf grafts programmed to induce regeneration
Our study reported the engineering of human hypertrophic cartilage as off-the-shelf material capable to induce resident cells toward developmentally inspired processes, leading to de novo bone formation. The unprecedented standardized osteoinductive performance, unmatched by commercially available materials or even living grafts, was critically dependent on a newly established, genetically-engineered human cell line.
Pigeot et al. 2021, Adv. Mater.